If their body become resistance to the insulin (their own), why they can accept the injected ones? are some of the components different compare to own insulin? I even heard some insulin injection called human insulin
In: Biology
It has nothing to do with the insulin being “accepted.” Their own naturally produced insulin still works, just not as well. So for example, they might need twice as much as normal, but their body is only producing a normal amount, so by injecting enough insulin to double when they currently are making, then they are now getting enough.
Essentially they need more insulin then most people, but their bodies only make the normal amount, so giving them some extra can help.
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Insulin resistance is not the same as insulin immunity. A patient with type 2 diabetes has functioning insulin receptors, but these don’t work as effectively as in normal people. Their ability to control blood glucose is only reduced.
Injecting insulin (human, synthetic or animal) will raise the insulin levels in the blood, further activating the insulin receptors. This increases the insulin-controlled response of muscle, fat and liver cells, and they begin absorbing blood glucose.
So it’s not that other insulin is more effective, it’s just a higher quantity of insulin raising the weakened response back to normal. Of course, you have to deal with the side effects of injecting insulin (Low blood sugar -> fainting, coma, lethargy, hassle and cost of injections, risks of infection etc).
As type 2 diabetes progresses over the years, insulin-producing cells in the pancreas can be slowly destroyed. The patient will then also have type-1 diabetes, so they will then need insulin injections to replace the lost production of insulin.
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