In a condensation between two amino acids, why does it take place between the amine end and the carboxylic end?

Question

I get that it’s supposed to form a peptide/amide bond, but why is that the two carboxylic ends won’t react?

In: Chemistry

Answer 1

Because the oxygen on the carboxylic end is a partial negative. Think back about a fundamental rule in chemistry, being that opposites attract (thus making the inverse true).

The NH3 on the amine end has a positive charge, and thus electrons from the carboxylic end satisfy that electron deficiency, forming the bond you’re referring to in a condensation reaction.

Answer 2

Are you just posting homework questions? Lol