It’s thought to be a disconnect between the visual motion you see and what your inner ear feels. Dramamine is a combination of diphenhydramine (Benadryl) and caffeine to combat some of the drowsiness diphenhydramine causes. It acts as an anti-cholinergic, which slows down signaling of some nerves in the brain, including those in the parts of the brain that mediate nausea.
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